Cell and tissue technologies

• Screening for antimicrobial agents
• Cell-based detection of pyrogens
• Virus-protection assay (Antiviral Assay, AVA)
• TCID₅₀ assay
• Plaque assay

The innate immune system has great influence on the pathogenesis or the course of diseases such as allergies, infections, tumors, or autoimmune diseases. With the help of immune receptors, we identify novel immunomodulatory molecules as potential drug candidates for the treatment of immunological diseases in (whole-cell) biosensor assays.

Our 3D skin models represent the complex physiology of the skin, including the intact skin barrier. By integrating immune cells and reporter systems to activate immune signaling pathways, they are suited for in-vitro testing of substances for toxicity, cell stress and allergenicity or immunomodulatory properties.

With our expertise in establishing new cell lines and expression vectors, we support pharmaceutical and biotechnology companies in the development of cell-based 2D and 3D assays as well as biologicals.

With the aid of a biosensor, an analyte can be detected via a biological element and a physical signal generated as a result. Biosensors are therefore suitable for a wide range of applications, from biotechnology to environmental physics. We develop biosensors for the detection of microbial components, which are used, among other things, for the detection of pyrogens and drinking water monitoring.