Cell and tissue technologies

On the one hand, the innovation field focuses on the development and establishment of human in-vitro test models such as 3D tissue models and cell-based 2D assays. On the other hand, those models are applied for the preclinical testing of drugs, the determination of toxicity and allergenicity of, e.g., cosmetics and chemicals, as well as for clinical applications in personalized medicine.

We have many years of expertise in the development of cell lines, for example to establish assays, the production of biologicals or the handling of (pathogenic) microorganisms.

A focus is on the integration of immune components into microphysiological tissues or reporter cell lines and the use of cell systems as biosensors.

In-vitro active substance and toxicity testing

 

Cell-based assays for diagnostics, quality control, screening

  • Screening for antimicrobial agents
  • Cell-based detection of pyrogens
  • Virus-protection assay (Antiviral Assay, AVA)
  • TCID50 assay
  • Plaque assay
 

Immune receptors and drug screening

The innate immune system has great influence on the pathogenesis or the course of diseases such as allergies, infections, tumors, or autoimmune diseases. With the help of immune receptors, we identify novel immunomodulatory molecules as potential drug candidates for the treatment of immunological diseases in (whole-cell) biosensor assays.

 

3D skin models as test system

Our 3D skin models represent the complex physiology of the skin, including the intact skin barrier. By integrating immune cells and reporter systems to activate immune signaling pathways, they are suited for in-vitro testing of substances for toxicity, cell stress and allergenicity or immunomodulatory properties.

 

Cell line development for 2D and 3D assays

With our expertise in establishing new cell lines and expression vectors, we support pharmaceutical and biotechnology companies in the development of cell-based 2D and 3D assays as well as biologicals.

 

Biosensors

With the aid of a biosensor, an analyte can be detected via a biological element and a physical signal generated as a result. Biosensors are therefore suitable for a wide range of applications, from biotechnology to environmental physics. We develop biosensors for the detection of microbial components, which are used, among other things, for the detection of pyrogens and drinking water monitoring.

Scientific publications from Dr. Anke Burger-Kentischer