Fraunhofer Institute for Interfacial Engineering and Biotechnology IGBWe have a broad bioprocess engineering know-how for process intensification and scale-up, whereby the processes developed on a laboratory scale are evaluated in advance with regard to their transferability to the industrial relevant scale and optimized iteratively during transfer and scale-up. These include the adaptation of process control strategies (batch, fed-batch, continuous) and integrated product purification to reduce process steps or the reuse of biocatalysts (e.g. by immobilization on carrier materials). In addition to the scale-up of processes to demonstration scale, we also provide sample quantities for application tests.
In der Pilotanlage am Fraunhofer-Zentrum für Chemisch-Biotechnologische Prozesse CBP stellen Forscher Erdölersatzstoffe aus nachwachsenden Rohstoffen her.
© Gunter Binsack / Fraunhofer CBP
Bioprocess scale-up
Tabbed contents
Services
Range of services
The team possesses broad bioprocess engineering expertise in the field of scale-up and process intensification. The processes developed on the laboratory scale are evaluated in the preliminary stages in terms of their transferability to industrially relevant equipment at scale and are optimized repetitively during transfer and scale-up. This includes, for example, the adjustment of process control strategies (batch, fed-batch, continuous) and integrated product purification to reduce the number of process steps or the reutilization of the deployed resources, e.g. by immobilization of biocatalysts on carrier materials.
Equipment
The equipment in the area of biotechnological processes comprises two modularly constructed pilot plant halls of biological safety level 1, whereby one of the halls can be operated under ATEX conditions.
Equipment
The facilities include a central microbiological laboratory, two module-based technical centers of the Biosafety Level 1, one of which can be operated under ATEX conditions.
Cultivation
- Fermentation of various microorganisms: reactor cascade with total volumes of 10, 100, 300, 1000 and 10,000 liters, equipped with four storage tanks each (acid, base, antifoaming agent, nutrition solution) as well as comprehensive automation, measurement and control technology (rotation speed, temperature, head space pressure, pH value, dissolved oxygen, respiration, methanol concentration)
- UHT plant for the continuous sterilization of fermentation media
- ATEX fermenter (total volume: 500 L) for conversion or production of highly flammable chemicals
- Continuous process control in fermentations by cell retention (sterilizable crossflow filtration plant with automatic feed level control)
- Online measurement of alcohol concentration in the reactor and of CO2/O2 in the fermentation exhaust gas
Enzymatic conversions
- Reactors for enzyme-catalyzed reactions (500 (mobile), 1300, 2000, 5000 and 10,000 liters, stirred, temperature-controlled)
- Enzymatic hydrolysis / modification of fibers (tank with special stirrer configuration for high viscosities)
Product purifcation and finishing
- Harvest of the fermentation suspension as well as temporary storage of product solutions using stirred and temperature-controlled tanks (500 (mobile) / 2,000 / 5,000 and 10,000 L)
- Biomass separation (disk separators 0.5 – 2 m3/h, 0.5 – 1 m3/h, vacuum drum cell flter 0.5 m2 and fiter press 1.6 m2)
- Cell disruption (homogenizer 0.4 m3/h, 1,000 bar, optional with subsequent flow cooling)
- Membrane filtration (MF/UF) for desalination and product concentration processes; feeding up to 500 kg/h; flexible use of spiral wound modules (material, cut-off)
- Fine purification using liquid chromatography (35-liter column volume, flow rate up to 180 L/h)
- Crystallizers (180 L, 800 L) with downstream vacuum fiter dryer (0.5 m2) in ATEX version
- Spray (5 kg/h) and freeze drying (0.8 m2) for finishing the products
Analytical equipment
- Laboratories for microbiological tests
- Qualitative and quantitative methods to determine the optical density and cell dry mass, the concentration of sugars, alcohols and organic acids, protein analysis
- Various assays for measuring enzyme activity
- Online measurement of the alcohol concentration in the reactor and CO2 / O2 in the fermentation exhaust gas
Publications
Wissenschaftliche Publikationen
| Jahr Year | Titel/Autor:in Title/Author | Publikationstyp Publication Type |
|---|---|---|
| 2024 | Process Cascade for the Production of Green Polymers from CO2 and Electric Energy Fabarius, Jonathan Thomas; Pietzka, Carsten; Pangotra, Dhananjai; Wriedt, Benjamin; Vieira Dessoy Maciel, Luciana; Sagstetter, Carina; Speck, Melanie; Ziogas, Athanassios; Baumgarten, Nils; Kost, Hans-Joachim; Löb, Patrick; Patzsch, Katja; Bernau, Catherine Rose; Böringer, Sarah; Pico, Davide; Lieske, Antje; Vater, Marcus; Wendler, Ulrich; Roth, Arne |
Zeitschriftenaufsatz Journal Article |
| 2024 | Past, present and future of glycolipids from Ustilaginaceae - A review on cellobiose lipids and mannosylerythritol lipids Münßinger, Sini; Beck, Alexander; Oraby, Amira; Zibek, Susanne |
Review |
| 2024 | Life cycle assessment as a driver for process optimisation of cellobiose lipids fermentation and purification Oraby, Amira; Briem, Ann-Kathrin; Bippus, Lars Ulrich; Rupp, Steffen; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2024 | Current trends in medium-chain-length polyhydroxyalkanoates: Microbial production, purification, and characterization Hahn, Thomas; Ortega Alzate, Melissa; Leonhardt, Steven; Tamang, Pravesh; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2024 | Comprehensive characterization and evaluation of the process chain and products from Euphausia superba exocuticles to chitosan Hahn, Thomas; Egger, Jeannine; Krake, Simon; Dyballa, Michael; Stegbauer, Linus; Seggern, Nils von; Bruheim, Inge; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2024 | Transmembrane Chemical Absorption Process for Recovering Ammonia as an Organic Fertilizer Using Citric Acid as the Trapping Solution Reyes Alva, Ricardo; Mohr, Marius; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2024 | Life cycle assessment for early-stage process optimization of microbial biosurfactant production using kinetic models - a case study on mannosylerythritol lipids (MEL) Bippus, Lars; Briem, Ann-Kathrin; Beck, Alexander; Zibek, Susanne; Albrecht, Stefan |
Zeitschriftenaufsatz Journal Article |
| 2023 | Fermentation and recovery of cellobiose lipids using foam fractionation Oraby, Amira; Hug, Daniel; Weickardt, Isabell; Maerz, Lea; Nebel, Sabrina; Kurmann, Jasper; Rupp, Steffen; Tovar, Günter E.M.; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2023 | Preliminary investigation on the effect of insect-based chitosan on preservation of coated fresh cherry tomatoes Tafi, Elena; Triunfo, Micaela; Guarnieri, Anna; Ianniciello, Dolores; Salvia, Rosanna; Scieuzo, Carmen; Ranieri, Annamaria; Castagna, Antonella; Lepuri, Samuel; Hahn, Thomas; Zibek, Susanne; Bonis, Angela de; Falabella, Patrizia |
Zeitschriftenaufsatz Journal Article |
| 2023 | Usage of chitosan from Hermetia illucens as a preservative for fresh Prunus species fruits: a preliminary analysis Triunfo, Micaela; Tafi, Elena; Guarnieri, Anna; Ianniciello, Dolores; Scieuzo, Carmen; Salvia, Rosanna; Hahn, Thomas; Zibek, Susanne; Falabella, Patrizia |
Zeitschriftenaufsatz Journal Article |
| 2022 | Techno-Economic Analysis as a Driver for Optimisation of Cellobiose Lipid Fermentation and Purification Oraby, Amira; Rupp, Steffen; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2022 | Optimization and Kinetic Modeling of a Fed-Batch Fermentation for Mannosylerythritol Lipids (MEL) Production with Moesziomyces aphidis Beck, Alexander; Vogt, Franziska; Hägele, Lorena; Rupp, Steffen; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2022 | Environmental Impacts of Biosurfactants from a Life Cycle Perspective Briem, Ann-Kathrin; Bippus, Lars; Oraby, Amira; Noll, Philipp; Zibek, Susanne; Albrecht, Stefan |
Aufsatz in Buch Book Article |
| 2022 | Purification of Chitin from Pupal Exuviae of the Black Soldier Fly Hahn, T.; Tafi, E.; Seggern, N. von; Falabella, P.; Salvia, R.; Thomä, J.; Febel, E.; Fijalkowska, M.; Schmitt, E.; Stegbauer, L.; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2022 | Characterization of chitin and chitosan derived from Hermetia illucens, a further step in a circular economy process Triunfo, M.; Tafi, E.; Guarnieri, A.; Salvia, R.; Scieuzo, C.; Hahn, Thomas; Zibek, Susanne; Gagliardini, A.; Panariello, L.; Coltelli, M.B.; Bonis , A. De; Falabella, P. |
Zeitschriftenaufsatz Journal Article |
| 2022 | Antimicrobial properties of chitosan from different developmental stages of the bioconverter insect Hermetia illucens Guarnieri, A.; Triunfo, M.; Scieuzo, C.; Ianniciello, D.; Tafi, E.; Hahn, Thomas; Zibek, Susanne; Salvia, R.; Bonis, A. De; Falabella, P. |
Zeitschriftenaufsatz Journal Article |
| 2022 | Overview on Glycosylated Lipids Produced by Bacteria and Fungi: Rhamno-, Sophoro-, Mannosylerythritol and Cellobiose Lipids Zibek, Susanne; Soberón-Chávez, Gloria |
Aufsatz in Buch Book Article |
| 2022 | Foam fractionation methods in aerobic fermentation processes Oraby, Amira; Weickardt, Isabell; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2021 | Novel mannosylerythritol lipid biosurfactant structures from castor oil revealed by advanced structure analysis Beck, A.; Haitz, Fabian; Thier, I.; Siems, K.; Jakupovic, S.; Rupp, S.; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2021 | Platform and fine chemicals from woody biomass: Demonstration and assessment of a novel biorefinery Nitzsche, R.; Gröngröft, A.; Köchermann, J.; Meisel, K.; Etzold, H.; Verges, Marlen; Bachmann, J.; Leschinsky, Moritz; Saake, B.; Torkler, Sandra; Rößiger, B.; Patzsch, Katja; Pufky-Heinrich, D.; Unkelbach, Gerd |
Zeitschriftenaufsatz Journal Article |
| 2021 | Genomic and Proteomic Study of Andreprevotia ripae Isolated from an Anthill Reveals an Extensive Repertoire of Chitinolytic Enzymes Lorentzen, S.B.; Arntzen, M.; Hahn, T.; Tuveng, T.R.; Sorlie, M.; Zibek, S.; Vaaje-Kolstad, G.; Eijsink, V.G.H. |
Zeitschriftenaufsatz Journal Article |
| 2021 | Insect Chitin-Based Nanomaterials for Innovative Cosmetics and Cosmeceuticals Triunfo, M.; Tafi, E.; Guarnieri, A.; Scieuzo, C.; Hahn, T.; Zibek, S.; Salvia, R.; Falabella, P. |
Review |
| 2020 | Antibacterial properties of glycosylated surfaces: Variation of the glucosidal moiety and fatty acid conformation of grafted microbial glycolipids Valotteau, C.; Roelants, S.L.K.V.; Dasaiyan, P.; Zibek, S.; Günther, Michael; Soetaert, W.; Everaert, B.; Pradier, C.-M.; Babonneau, F.; Baccile, N.; Humblot, V. |
Zeitschriftenaufsatz Journal Article |
| 2020 | Draft Genome Sequence of Andreprevotia sp. Strain IGB-42, a Chitinolytic Bacterium Isolated from a Soil Sample of an Anthill in Stuttgart, Germany Vainshtein, Y.; Werner, Nicole; Kirstahler, Philipp; Glanz, K.; Grumaz, Christian; Hahn, T.; Zibek, S.; Sohn, K. |
Zeitschriftenaufsatz Journal Article |
| 2020 | Chitosan application in textile processing and fabric coating Hahn, Thomas; Bossog, Leonie; Hager, Tom; Wunderlich, Werner; Breier, Rudi; Stegmaier, TThomas; Zibek, Susanne |
Aufsatz in Buch Book Article |
| 2020 | Mannosylerythritollipide - mikrobielle Biotenside aus dem Bioreaktor Beck, A.; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2020 | Current state of chitin purification and chitosan production from insects Hahn, T.; Tafi, E.; Paul, A.; Salvia, R.; Falabella, P.; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2020 | Determining different impact factors on the xylonic acid production using Gluconobacter oxydans DSM 2343 Hahn, T.; Torkler, S.; Bolt, R. van der; Gammel, N.; Hesse, M.; Möller, A.; Preylowski, B.; Hubracht, V.; Patzsch, K.; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2020 | Factors Affecting the Synthesis of Cellobiose Lipids by Sporisorium scitamineum Oraby, Amira; Werner, Nicole; Sungur, Z.; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2020 | Growth Behavior of Selected Ustilaginaceae Fungi Used for Mannosylerythritol Lipid (MEL) Biosurfactant Production - Evaluation of a Defined Culture Medium Beck, A.; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2020 | Chitosan production with larval exoskeletons derived from the insect protein production Hahn, T.; Roth, A.; Ji, R.; Schmitt, E.; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2020 | A systematic analysis of economic evaluation studies of second-generation biorefineries providing chemicals by applying biotechnological processes Jorissen, T.; Oraby, Amira; Recke, G.; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2020 | Comparison of Different Lactobacilli Regarding Substrate Utilization and their Tolerance Towards Lignocellulose Degradation Products Gubelt, A.; Blaschke, Lisa; Hahn, Thomas; Rupp, Steffen; Hirth, Thomas; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2019 | Biotechnological and biochemical utilization of lignin Rais, Dominik; Zibek, Susanne |
Aufsatz in Buch Book Article |
| 2019 | Selection and optimization of a suitable pretreatment method for miscanthus and poplar raw material Seibert-Ludwig, Daniel; Hahn, Thomas; Hirth, Thomas; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2019 | Influence of microorganism and plant oils on the structure of mannosylerythritol lipid (MEL) biosurfactants revealed by a novel thin layer chromatography mass spectrometry method Beck, Alexander; Haitz, Fabian; Grunwald, Saskia; Preuss, Laura; Rupp, Steffen; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2019 | Stirrer speed adaption is beneficial for liquefaction of cellulose Hahn, Thomas; Nothacker, Matthias; Kövilein, Aline; Beck, Alexander; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2019 | Mannosylerythritol Lipids: Biosynthesis, Genetics, and Production Strategies Beck, Alexander; Werner, Nicole; Zibek, Susanne |
Aufsatz in Buch Book Article |
| 2019 | Integrated lignocellulosic value chains in a growing bioeconomy: Status quo and perspectives Dahmen, Nicolaus; Lewandowski, Iris; Zibek, Susanne; Weidtmann, Annette |
Zeitschriftenaufsatz Journal Article |
| 2018 | Chemo-Enzymatic Epoxidation of Lallemantia IbericaSeed Oil Haitz, Fabian; Radloff, S.; Rupp, S.; Fröhling, M.; Hirth, Thomas; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2018 | Entwicklung von Verfahren zur enzymatischen Epoxidierung von Pflanzenölen und Fettsäurederivaten Haitz, F. |
Dissertation Doctoral Thesis |
| 2018 | Sewage Polluted Water Treatment via Chitosan. A Review Hahn, Thomas; Zibek, Susanne |
Aufsatz in Buch Book Article |
| 2018 | Unkraut kann auch anders. Handschuhe aus Russischem Löwenzahn Hahn, Thomas; Abele, A.; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2018 | New methods for high-accuracy insect chitin measurement Hahn, T.; Roth, A.; Febel, E.; Fijalkowska, M.; Schmitt, E.; Arsiwalla, T.; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2017 | Development of a simplified purification method for a novel formaldehyde dismutase variant from Pseudomonas putida J3 Blaschke, Lisa; Werkmeister, Christina; Wagner, Wenke; Wild, Marion; Gihring, Adrian; Rupp, Steffen; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2017 | Mannosylerythritol- und Cellobioselipide Hahn, T.; Haitz, Fabian; Schäper, N.; Carrillo Riveros, P.; Günther, Michael; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2017 | Verfahren zur Herstellung von Epoxiden mit Hilfe von Enzymen mit Perhydrolaseaktivität Zibek, Susanne |
Patent |
| 2017 | Biotechnological production of bio-based long-chain dicarboxylic acids with oleogenious yeasts Werner, Nicole; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2017 | Beechwood carbohydrates for enzymatic synthesis of sustainable glycolipids Siebenhaller, S.; Hajek, T.; Muhle-Goll, C.; Himmelsbach, M.; Luy, B.; Kirschhöfer, F.; Brenner-Weiß, G.; Hahn, T.; Zibek, S.; Syldatk, C. |
Zeitschriftenaufsatz Journal Article |
| 2017 | Candida guilliermondii as a potential biocatalyst for the production of long-chain a,o-dicarboxylic acids Werner, Nicole; Dreyer, Miriam; Wagner, Wenke; Papon, Nicolas; Rupp, Steffen; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2017 | Draft genome sequence of Pseudonocardia autotrophica strain DSM 43083, an efficient producer of peroxidases for lignin modification Grumaz, Christian; Rais, Dominik; Kirstahler, Philipp; Vainshtein, Yevhen; Rupp, Steffen; Zibek, Susanne; Sohn, Kai |
Zeitschriftenaufsatz Journal Article |
| 2017 | Sustainable carbon sources for microbial organic acid production with filamentous fungi Dörsam, S.; Fesseler, J.; Gorte, O.; Hahn, T.; Zibek, S.; Syldatk, C.; Ochsenreither, K. |
Zeitschriftenaufsatz Journal Article |
| 2017 | Biotechnological Routes Towards Bio-based Surfactants Schörken, U.; Barbe, S.; Hahn, T.; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2017 | Neue Biokatalysatoren zur Herstellung langkettiger Dicarbonsäuren Werner, Nicole; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2017 | Fungal Glycolipids as Biosurfactants Günther, Michael; Zibek, S.; Rupp, S. |
Zeitschriftenaufsatz Journal Article |
| 2016 | Scale-up of the chemo-enzymatic epoxidation Haitz, Fabian; Rupp , Steffen; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2016 | Optimization and scale-up of inulin extraction from Taraxacum koksaghyz Hahn, Thomas; Harms, Karsten; Wach, Wolfgang; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2016 | Chitin-converting enzymes Moß, K.; Zibek, S.; Hirth, Thomas; Rupp, S. |
Aufsatz in Buch Book Article |
| 2016 | Fermentative production and characterization of several tailor-made mannosylerythritol lipids Zibek, Susanne; Günther, Michael; Carillo-Riveros, Paula; Hirth, Thomas |
Zeitschriftenaufsatz Journal Article |
| 2016 | Enzymatische Synthese von Biotensiden aus der Cellulosefraktion des Organosolvprozesses Siebenhaller, Sascha; Hajek, T.; Zibek, Susanne; Syldatk, Christoph |
Zeitschriftenaufsatz Journal Article |
| 2016 | Sustainable enzymatic synthesis of glycolipids in a deep eutectic solvent system Siebenhaller, S.; Muhle-Goll, C.; Luy, B.; Kirschhöfer, F.; Brenner-Weiss, G.; Hiller, Ekkehard; Günther, Michael; Rupp, S.; Zibek, S.; Syldatk, C. |
Zeitschriftenaufsatz Journal Article |
| 2016 | pH-driven self-assembly of acidic microbial glycolipids Baccile, Niki; Selmane, Mohamed; Griel, Patrick le; Prévost, Sylvain; Perez, Javier; Stevens, Christian V.; Delbeke, Elisabeth; Zibek, Susanne; Guenther, Michael; Soetaert, Wim; Bogaert, Inge N.A. van; Roelants, Sophie |
Zeitschriftenaufsatz Journal Article |
| 2016 | ChitoTex - development and production of new insect chitosan and chitosan-based functional coatings for textiles Hahn, Thomas; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2016 | Herstellung langkettiger a,o-Dicarbonsäuren. Mikrobielle Verwertung von nachwachsenden Rohstoffen der zweiten Generation Riepe, Bianca; Vater, Björn; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2016 | Seasonal pattern of biomass and rubber and inulin of wild Russian dandelion (Taraxacum koksaghyz L. Rodin) under experimental field conditions Kreuzberger, Marie; Hahn, Thomas; Zibek, Susanne; Schiemann, Joachim; Thiele, Katja |
Zeitschriftenaufsatz Journal Article |
| 2016 | Optimization and scale-up of inulin extraction from Taraxacum kok-saghyz roots Hahn, Thomas; Klemm, Andrea; Zieße, Patrick; Harms, Karsten; Wach, Wolfgang; Rupp, Steffen; Hirth, Thomas; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2015 | Expression of a codon-optimized Carica papaya papain sequence in the methylotrophic yeast pichia pastoris Werner, Nicole; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2015 | Enzymatic hydrolysis of solid substrates: Critical notes and experimental guidelines for improvements Hahn, Thomas; Haitz, Fabian; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2015 | Transcriptomic profiling of Pseudozyma aphidis during mannosylerythritol lipid synthesis Günther, Michael; Grumaz, Christian; Lorenz, Stefan; Stevens, Philip; Lindemann, Elena; Hirth, Thomas; Sohn, Kai; Zibek, Susanne; Rupp, Steffen |
Zeitschriftenaufsatz Journal Article |
| 2015 | Lipase-catalyzed epoxidation of fatty compounds and alkenes Haitz, Fabian; Rupp, Steffen; Hirth, Thomas; Zibek, Susanne |
Aufsatz in Buch Book Article |
| 2015 | Enzymatische Verzuckerung von Lignozellulose Vater, Björn; Hirth, Thomas; Rupp, Steffen |
Zeitschriftenaufsatz Journal Article |
| 2015 | Integrierte Bioproduktion - Pflanzliche Öle für die chemische Industrie Torkler, Sandra; Haitz, Fabian; Zibek, Susanne; Patzsch, Katja; Hirth, Thomas |
Zeitschriftenaufsatz Journal Article |
| 2015 | The transcriptomic profile of Pseudozyma aphidis during production of mannosylerythritol lipids Günther, Michael; Grumaz, Christian; Lorenz, Stefan; Stevens, Philip; Lindemann, Elena; Hirth, Thomas; Sohn, K.; Zibek, S.; Rupp, S. |
Zeitschriftenaufsatz Journal Article |
| 2015 | Draft genome sequence of Amantichitinum ursilacus IGB-41, a new chitin-degrading bacterium Kirstahler, Philipp; Günther, Michael; Grumaz, Christian; Lindemann, Elena; Rupp, Steffen; Zibek, Susanne; Sohn, Kai |
Zeitschriftenaufsatz Journal Article |
| 2015 | Development of new biocatalysts and process optimization for the production of long-chain a,o-dicarboxylic acids Werner, Nicole; Riepe, Bianca; Vater, Björn; Geiger, Georg; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2015 | Identification of new CALB-type lipases within the genus Pseudozyma Sabatini, Selina; Schultz, Elisabeth; Helber, Nicole; Rupp, Steffen; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2015 | Vom Schüttelkolben in die Pilotanlage: Enzymherstellung in Hefen Werner, Nicole; Vater, B.; Elter, T.; Patzsch, K.; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2014 | High solids enzymatic hydrolysis of pretreated lignocellulosic materials with a powerful stirrer concept Ludwig, D.; Buchmann, M.; Hirth, Thomas; Rupp, S.; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2014 | Entwicklung neuer Biokatalysatoren für die Herstellung von langkettigen Dicarbonsäuren Helber, Nicole; Rupp, Steffen; Hirth, Thomas; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2014 | Enzymatische Verzuckerung von Lignozellulose Vater, Björn; Hirth, Thomas; Rupp, Steffen |
Zeitschriftenaufsatz Journal Article |
| 2014 | Neue Verfahren für die Ligninmodifikation am Beispiel der Natur Zibek, Susanne; Rais, Dominik; Rupp, Steffen; Hirth, Thomas |
Zeitschriftenaufsatz Journal Article |
| 2014 | Herstellung biozertifizierter Kosmetika aus nachwachsenden Rohstoffen Vásquez-Caicedo, Ana Lucia; Zibek, Susanne; Rupp, Steffen; Egner, Siegfried |
Zeitschriftenaufsatz Journal Article |
| 2014 | Neue Enzyme für eine Methanol-basierte grüne Chemie Zibek, Susanne; Blaschke, Lisa; Hirth, Thomas; Rupp, Steffen |
Zeitschriftenaufsatz Journal Article |
| 2014 | Integrierte Bioproduktion - Integrierte chemisch-biotechnologische Herstellung von Synthesebausteinen auf der Basis pflanzlicher Öle Zibek, Susanne; Rupp, Steffen; Hirth, Thomas |
Zeitschriftenaufsatz Journal Article |
| 2014 | Synthese von Mannosylerythritollipide von Pseudozyma-Spezies mit nachwachsenden Rohstoffen Zibek, Susanne; Hirth, Thomas; Rupp, Steffen; Carrillo Riveros, Paula Alejandra |
Zeitschriftenaufsatz Journal Article |
| 2014 | Optimierung und Scale-up der enzymatischen Hydrolyse inkl. Ligninabbau Tippkötter, Nils; Duwe, Anna; Rais, Dominik; Zibek, Susanne; Zorn, H. |
Zeitschriftenaufsatz Journal Article |
| 2014 | Demonstration der fermentativen Herstellung von Isobuten im Pilotmaßstab Elter, Tino; Buhl, T. |
Zeitschriftenaufsatz Journal Article |
| 2014 | Identifizierung neuer bakterieller Lignin-modifizierender Enzyme Zibek, Susanne; Rais, Dominik; Rupp, Steffen; Hirth, Thomas |
Zeitschriftenaufsatz Journal Article |
| 2014 | Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids Lorenz, Stefan; Günther, Michael; Grumaz, Christian; Rupp, Steffen; Zibek, Susanne; Sohn, Kai |
Zeitschriftenaufsatz Journal Article |
| 2014 | Herstellung von Enzymen - Maßstabsübertragung vom Laborprozess zur Pilotanlage Helber, Nicole; Vater, Björn; Haitz, Fabian; Torkler, Sandra; Patzsch, Katja; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2013 | Lignin als nachwachsende Rohstoffquelle Staiger, Nadine; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2013 | Lokale chemische Stimulation von Zelllinien durch Dispensieren von Tropfen mit dem StimuDrop Zibek, S. |
Dissertation Doctoral Thesis |
| 2013 | Amantichitinum ursilacus gen. nov., sp nov., a chitin-degrading bacterium isolated from soil Moß, K.; Hartmann, S.C.; Müller, I.; Fritz, C.; Krügener, Sven; Zibek, S.; Hirth, Thomas; Rupp, S. |
Zeitschriftenaufsatz Journal Article |
| 2013 | Characterization of novel mutants with an altered gibberellin spectrum in comparison to different wild-type strains of Fusarium fujikuroi Albermann, S.; Elter, T.; Teubner, A.; Krischke, W.; Hirth, Thomas; Tudzynski, B. |
Zeitschriftenaufsatz Journal Article |
| 2013 | Produktion von Biotensiden mit Pseudozyma-Stämmen Günther, Michael; Hirth, Thomas; Zibek, S.; Rupp, S. |
Zeitschriftenaufsatz Journal Article |
| 2013 | Herstellung Pflanzenöl-basierter Epoxide Haitz, Fabian; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne |
Zeitschriftenaufsatz Journal Article |
| 2013 | Development and optimization of single and combined detoxification processes to improve the fermentability of lignocellulose hydrolyzates Ludwig, D.; Amann, M.; Hirth, Thomas; Rupp, S.; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2012 | Comparison of chemo-enzymatic epoxidation of oleic acid with different immobilized lipases Haitz, Fabian; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne |
Konferenzbeitrag Conference Paper |
| 2012 | Untersuchungen zur Synthese von optimierten Mannosylerythritollipiden Zibek, S.; Günther, Michael; Hirth, Thomas; Rupp, S. |
Zeitschriftenaufsatz Journal Article |
| 2012 | Selektive Konversion lignocellulosehaltiger Materialien als Plattformtechnologie für biobasierte Chemikalien Zibek, S.; Ludwig, D.; Hirth, Thomas; Rupp, S. |
Zeitschriftenaufsatz Journal Article |
Diese Liste ist ein Auszug aus der Publikationsplattform Fraunhofer-Publica
This list has been generated from the publication platform Fraunhofer-Publica
| Jahr Year | Titel/Autor:in Title/Author | Publikationstyp Publication Type |
|---|---|---|
| 2012 | Untersuchung der Stickstoffregulation der Gibberellin-Synthese von Fusarium fujikuroi Elter, T.; Albermann, S.; Krischke, W.; Hirth, Thomas; Tudzynski, B. |
Zeitschriftenaufsatz Journal Article |
| 2012 | Milchsäurebakterien für die Herstellung von Milchsäure aus Weizenstroh Zibek, S.; Gronen, A.; Hirth, Thomas; Rupp, S. |
Zeitschriftenaufsatz Journal Article |
| 2012 | Stoffliche Nutzung von Lignin. Ein Beitrag zur ganzheitlichen stofflichen Nutzung von Biomasse. Tl. 2: Chemische und biochemische Spaltung von Lignin in Aromaten Hirth, Thomas; Unkelbach, G.; Zibek, S.; Staiger, Nadine; Leschinsky, Moritz |
Zeitschriftenaufsatz Journal Article |
| 2012 | Process development for high-solid enzymatic conversion of lignocellulose within a biorefinery Ludwig, Daniel; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne |
Konferenzbeitrag Conference Paper |
| 2011 | Chemo-enzymatic epoxidation of fatty acids and triacylglycerides from various plant oils Haitz, Fabian; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne |
Konferenzbeitrag Conference Paper |
| 2011 | Chitin-converting enzymes Moß, K.; Zibek, S.; Hirth, Thomas; Rupp, S. |
Aufsatz in Buch Book Article |
| 2011 | Co-cultured production of lignin-modifying enzymes with white-rot fungi and its potential application Krügener, Sven; Qi-he, Chen; Hirth, Thomas; Zibek, Susanne; Rupp, Steffen |
Konferenzbeitrag Conference Paper |
| 2011 | Biobasierte Monomere und Polymere Hirth, Thomas; Fehrenbacher, Ulrich; Kowollik, Kristian; Krischke, Wolfgang; Krügener, Sven; Rupp, Steffen; Schweppe, Rainer; Unkelbach, Gerd; Zibek, Susanne |
Aufsatz in Buch Book Article |
| 2011 | Biotechnological synthesis of long-chain dicarboxylic acids as building blocks for polymers Huf, Sabine; Krügener, Sven; Hirth, Thomas; Rupp, S.; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2011 | Co-cultured production of lignin-modifying enzymes with white-rot fungi Qi-he, C.; Krügener, Sven; Hirth, Thomas; Rupp, S.; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2011 | From lignocellulose to platform chemicals Ludwig, Daniel; Gronen, Angela; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne |
Konferenzbeitrag Conference Paper |
| 2010 | Screening for microorganisms for the synthesis of acetic acid and lactic acid out of wheat straw hydrolysate at low pH Gronen, A.; Hirth, Thomas; Rupp, S.; Zibek, S. |
Konferenzbeitrag Conference Paper |
| 2010 | Wheat straw - making a natural carbon source accessible for industry Ludwig, Daniel; Hirth, Thomas; Rupp, S.; Zibek, S. |
Konferenzbeitrag Conference Paper |
| 2010 | Synthese und Optimierung von Cellobioselipiden und Mannosylerythritollipiden Rupp, S.; Zibek, S.; Günther, M.; Hirth, Thomas |
Konferenzbeitrag Conference Paper |
| 2010 | Identification of qualified microorganisms for the usage of wheat straw hydrolysate for the synthesis of acetic acid and lactic acid Gronen, A.; Hirth, Thomas; Rupp, S.; Zibek, S. |
Konferenzbeitrag Conference Paper |
| 2010 | Mikroorganismen zur stofflichen Nutzung von Stroh-Hydrolysat Gronen, A.; Hirth, Thomas; Rupp, S.; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2010 | Production and optimization of cellobiose lipids and mannosylerythritol lipids Günther, M.; Hirth, Thomas; Rupp, S.; Zibek, S. |
Konferenzbeitrag Conference Paper |
| 2010 | Mikrobielle Synthese von Biotensiden Günther, Michael; Zibek, S.; Hirth, Thomas; Rupp, S. |
Zeitschriftenaufsatz Journal Article |
| 2010 | Identification of yeast strains for the synthesis of a,w-dicarboxylic acids Huf, S.; Wagner, Wenke; Hirth, Thomas; Zibek, S.; Rupp, S. |
Konferenzbeitrag Conference Paper |
| 2010 | Stoffliche Nutzung von Lignocellulose - Detoxifikation von Aufschlusslösungen mit immobilisierter Laccase Ludwig, D.; Amann, M.; Hirth, Thomas; Rupp, S.; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2010 | Selective synthesis and tailoring of glycolipid biosufactants Günther, M.; Hirth, Thomas; Rupp, S.; Zibek, S. |
Konferenzbeitrag Conference Paper |
| 2010 | New chitinolytic organisms for the degradation of chitin to N-acetylglucosamine Moß, K.; Hirth, Thomas; Rupp, S.; Zibek, S. |
Konferenzbeitrag Conference Paper |
| 2010 | Expression of codon optimized Bacillus cereus Phospholipase C in Kluyveromyces lactis Krügener, Sven; Hirth, Thomas; Zibek, S.; Rupp, S. |
Konferenzbeitrag Conference Paper |
| 2010 | Production of a,w-dicarboxylic acids via biotransformation of fatty acids by the use of Candida tropicalis Huf, S.; Wagner, Wenke; Hirth, Thomas; Rupp, S.; Zibek, S. |
Konferenzbeitrag Conference Paper |
| 2010 | Wheat straw - making a natural carbon source accessible for industry Ludwig, Daniel; Hirth, Thomas; Rupp, S.; Zibek, S. |
Konferenzbeitrag Conference Paper |
| 2010 | Biotechnological process development for the production of C5 and C6 sugars as bio-based building blocks from lignocellulose Ludwig, Daniel; Hirth, Thomas; Rupp, S.; Zibek, S. |
Konferenzbeitrag Conference Paper |
| 2010 | Production of alpha-, omega-dicarboxylic acids via biotransformation of fatty acids by the use of Candida tropicalis Huf, S.; Wagner, Wenke; Hirth, Thomas; Rupp, S.; Zibek, S. |
Konferenzbeitrag Conference Paper |
| 2010 | Weizenstroh - Eine potenzielle Rohstoffquelle für die chemische Industrie Ludwig, D.; Hirth, Thomas; Rupp, S.; Zibek, S. |
Zeitschriftenaufsatz Journal Article |
| 2010 | Laccase-katalysierte Detoxifizierung von löslichen Ligninabbauprodukten in vorbehandelten Lignocellulose-Hydrolysaten Zibek, S.; Rupp, S.; Hirth, Thomas; Amann, M.; Ludwig, Daniel |
Konferenzbeitrag Conference Paper |
| 2009 | Prozessentwicklung zur Herstellung von NAG mit neuen Chitinasen Moß, K.; Zibek, S.; Hirth, Thomas; Rupp, S. |
Konferenzbeitrag Conference Paper |
| 2009 | New chitinases for the industrial biotechnology Moß, K.; Zibek, S.; Hirth, Thomas; Rupp, S. |
Konferenzbeitrag Conference Paper |
| 2009 | Fermentative Herstellung der α,ω-Dicarbonsäure 1,18-Oktadecendisäure als Grundbaustein für biobasierte Kunststoffe Zibek, Susanne; Huf, Sabine; Wagner, Wenke; Hirth, Thomas; Rupp, S. |
Zeitschriftenaufsatz Journal Article |
Diese Liste ist ein Auszug aus der Publikationsplattform Fraunhofer-Publica
This list has been generated from the publication platform Fraunhofer-Publica
Team
Group photo »Bioprocess scale-up«