Fraunhofer Institute for Interfacial Engineering and Biotechnology IGBThe interaction of the biological system with the biomaterial is influenced decisively by the surface properties such as the topography and the chemical composition (roughness, functional groups, chemical potential, swelling capability, hardness). We examine the chemistry and physics of the interfaces with a wide range of methods. Using modern imaging processes, for example, we can represent the topography of the surface down to the sub-nanometer range and also make the chemical composition or protein adsorption visible with integrated spatial resolution.